Nobiletin Ameliorates Doxorubicin-Induced Nephrotoxicity by Targeting Oxidative Stress, Inflammatory, and Apoptotic Pathways: Combined <i>In Vivo</i> and <i>In Silico</i> Insights.

The resulting network comprised 14 nodes and 87 edges with a highly significant enrichment (p-value <1.0e–16), indicating nonrandom functional connectivity among apoptosis, inflammation, and oxidative-stress regulators.

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Although differences were noted among the nobiletin (0.33 ± 0.05 a b ), silymarin (0.43 ± 0.06 a b ), and tangeretin (0.56 ± 0.11 a b ) groups, these did not reach statistical significance ( p > 0.05), suggesting similar histological protection by all compounds.

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