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Stigmasterol upregulates PDGFRα, contributing to white matter protection and anxiolytic-like behavior in a mouse model of vanadium-induced demyelination.

Front Neurol · 2026 · PMC12903120 · PMID 41695634

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Although alterations in microglial activation (Iba-1), astrocytic response (GFAP), and neuronal density (NeuN) were observed, these changes did not reach statistical significance ( Figures 6a – d ).

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