Comparative efficacy, immune response, and safety of mRNA versus dendritic cell vaccines in solid tumors: a systematic review and meta-analysis.

J Transl Med · 2026 · PMC12903260 · PMID 41689073

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.1230

boldest claim

The sentences

highly significantp < 0.001actually significant

This difference was highly significant, as evidenced by a chi-square statistic of 142.8 ( df = 1, p < 0.001, Fig. 4 a).

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did not reach statistical significancep = 0.123not close (p > 0.1)

Although the pooled ORR and DCR were numerically higher for mRNA vaccines, these differences did not reach statistical significance (ORR: β = − 0.63, p = 0.123; DCR: β = -0.37, p = 0.239).

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