Leveraging protein language models to identify complex trait associations with previously inaccessible classes of functional rare variants.

Two of the four ( DNM2 ∼ LDL and TARS2 ∼ height) gene-trait pairs were replicated (beta = −0.203, SE = 0.089, p = 0.012 and beta = 0.053, SE = 0.018, p = 0.001 from the burden test, respectively) after multiple testing adjustment and another association ( ACAN -height) was nominally significant (beta = −0.094, SE = 0.045, p = 0.025 from the burden test).

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