Identification of antidepressant response-related changes to DNA methylation and gene expression.

Int J Neuropsychopharmacol · 2026 · PMC12903956 · PMID 41593764

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0520

boldest claim

The sentences

highly significantP =.0000015actually significant

Although they do not pass correction for multiple testing in this analysis, the sites in SCN7A and IQANK1 remain highly significant (unadjusted P =.0000015 and .0000035, respectively) and are among the top 10 most significant sites.

also in 132,142 other papers

nominally significantP = .052so close (0.05 < p ≤ 0.1)

Additionally, all sites remained nominally significant in our mixed effects model in which we controlled for age, sex, and the first 4 principal components ( Table S3 ), with the exception of GOLGA3 (unadjusted P = .052).

also in 7,732 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.