GLP-1 and the cardiovascular system.

J Clin Invest · 2026 · PMC12904707 · PMID 41697744

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did not reach statistical significanceno p-value reported

The recently completed SOUL trial further elucidated the CV benefits of oral semaglutide, addressing the limitations observed in the earlier PIONEER-6 trial, where a reduction in MACE did not reach statistical significance ( 55 ).

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