PPP2R2A insufficiency enhances PD-L1 immune checkpoint blockade efficacy in lung cancer through cGAS-STING activation.

After we controlled for the level of TMB in the Cox proportional hazard regression model, the association between PPP2R2A shallow deletion and patient survival in Supplemental Figure 2 was slightly changed, but the difference did not reach statistical significance (for disease-free interval and disease-specific survival, P = 0.15 and 0.06, respectively, after controlling for TMB level) ( Supplemental Table 1 ).

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