Population-scale analysis reveals inherited C1-inhibitor deficiency is a polyphenotypic thrombotic disorder.

At a threshold of FIS ≥0.7, SERPING1 variant carriers had a nominally significant increased risk of NCEIS (HR, 3.29; 95% CI, 1.06-10.19; P = .039) and PAD (HR, 3.10; 95% CI, 1.29-7.45; P = .011), with the association for PAD remaining significant after Bonferroni correction ( Figure 2 C; supplemental Table 4 ).

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