Colostrum extracellular vesicles are neuroprotective in models of Parkinson's disease.

Nine of the ten genes showed a decreasing trend in the MPTP+C-EV group compared to the MPTP group, but none were statistically significant.

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C-EV treatment administered before and on the day of MPTP intoxication showed a trend toward increased survival of dopaminergic neurons in the substantia nigra (SN), although the difference was not statistically significant when compared with mice treated with MPTP alone ( Figure S1 A-B).

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The results demonstrated that CCR6 and S100a4 were significantly increased (p < 0.05), while LCN2, Chil3, CCL21 , and CCL4 showed an increasing trend in MPTP mice compared to that in PBS controls.

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