Multivariate integrated predictive model for 1-year mortality risk prognosis in patients undergoing esophageal cancer resection: establishment and validation.

Impact of NPS score and Clavien-Dindo classification on 1-year survival outcomes in esophageal cancer patients postoperative (Kaplan-Meier analysis) Kaplan-Meier survival curve analysis based on the Naples Prognostic Score (NPS, as a nutritional and inflammatory indicator) and Clavien-Dindo classification revealed a highly significant statistical difference ( p < 0.0001) in survival curves between the NPS < 3 group (NPS = 1) and the NPS ≥ 3 group (NPS = 2) among esophageal cancer patients after surgery.

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Although the American Society of Anesthesiologists (ASA) classification did not reach statistical significance in the multivariate model, it was retained due to its recognized value in clinical anesthetic risk assessment, enhancing the model’s clinical applicability.Notably, updated multivariate Cox analysis confirmed WBC as an independent predictor of postoperative 1-year mortality (adjusted HR = 1.12, 95% CI: 1.05–1.19, P = 0.001), whereas the neutrophil-to-lymphocyte ratio (NLR) — despite approaching statistical significance in univariate analysis (HR = 1.05, 95% CI: 1.00–1.10, P = 0.05) — did not reach significance in the multivariate model (adjusted HR = 1.05, 95% CI: 0.99–1.11, P = 0.124).

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