CMS subtypes correlate with complete response in trial of neoadjuvant Galunisertib plus chemoradiation in rectal cancer.

Transl Oncol · 2026 · PMC12906146 · PMID 41653703

Europe PMC DOI

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0.0512

closest p · 1.0× alpha

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boldest claim

The sentences

a trend towards significancep=0.0512so close (0.05 < p ≤ 0.1)

However, there was a significant association between high/medium endothelial TGFβ response signature (E-TBRS) and complete response when all time points were combined ( Supplementary Figure 3Fiii , Fisher exact test p=0.0253), and a trend towards significance with all timepoints combined for the macrophage signature (M-TBRS, Supplemental Figure 3Diii , Fisher exact test p=0.0512).

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did not reach statistical significanceno p-value reported

We evaluated whether RSS predicted response in our cohort of patients and found that patients with CR had a higher average RSS, but this did not reach statistical significance ( Fig. 2A , Day 0: 0.5037 [CR] vs 0.4254 [<CR], NS; Day 15: 0.5687 [CR] vs 0.5037 [<CR], NS).

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