Hepatic cholate clearance as assessed by HepQuant-SHUNT is associated with clinical outcomes in individuals with Fontan circulation.

Int J Cardiol Congenit Heart Dis · 2026 · PMC12906153 · PMID 41695267

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highly significantno p-value reported

Of note, institution was highly significant with NU participants having an over 7-fold higher odds of composite outcome compared to the Penn cohort.

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showed a trendno p-value reported

Transplant-free survival stratified by SHUNT% showed a trend towards lower survival for those with elevated SHUNT% over the entire follow-up period ( Fig. 1 ).

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