Genetically Predicted Homocysteine Levels and B Vitamins on Sarcopenia-Related Traits: Insights From an Observational and Mendelian Randomization Analysis.

Although the MR Egger (bootstrap) analysis showed a borderline significant positive association ( β = 0.052, 95% CI = −0.004 to 0.104, p = 0.008), this finding is not conclusive, given that its confidence interval contains zero values and is inconsistent with the results of other analytical methods.

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This result was directionally consistent with estimates from sensitivity analyses, including the weighted median (OR = 1.07, 95% CI: 0.93–1.23), Simple mode (OR = 1.07, 95% CI: 0.87–1.30), Weighted mode (OR = 1.06, 95% CI: 0.91–1.25) and MR‐Egger methods, though these did not reach statistical significance.

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