Truncated FOS impairs osteogenic differentiation and induces prostaglandin and NFκB signalling in an in vitro cell-of-origin model for osteoid osteoma and osteoblastoma.

ALPL RNA expression and ALP activity showed a trend towards reduction in fMSCs overexpressing FOSΔ compared to pLV, although this was not statistically significant ( p = 0.2 for ALPL expression and p = 0.1 for ALP activity) (Figure 2C,D ). fMSCs overexpressing FOS FL further reduced ALPL expression (although not significant, p = 0.2) and ALP activity ( p ≤ 0.0001) compared to wild‐type fMSCs (pLV) (Figure 2C,D ).

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