Barely Significant
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Comparative risk of <i>Clostridioides difficile</i> infection in patients with Crohn's disease receiving ustekinumab versus anti-TNF therapy: a retrospective cohort study.

Ther Adv Gastroenterol · 2026 · PMC12909749 · PMID 41710775

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0.1020
closest p · 2.0× alpha
0.1020
boldest claim

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did not reach statistical significancep = 0.102not close (p > 0.1)
An exploratory sensitivity analysis in biologic-naïve patients yielded an adjusted HR of 0.27 (95% CI: 0.05–1.30), which did not reach statistical significance ( p = 0.102).

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