Aged skin exacerbates experimental osteoarthritis via enhanced IL-36R signaling.

Nat Commun · 2026 · PMC12909930 · PMID 41530151

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did not reach statistical significanceno p-value reported

Subchondral bone sclerosis and osteophyte formation did not reach statistical significance in some groups, possibly due to the DMM model, which typically induces milder subchondral bone changes than the ACLT model 49 , 50 .

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