Investigating the Landscape of C6-Azaindole Side Chain on the Epoxymorphinan Skeleton via the Nitrogen Walk Concept: A Strategy to Enhance Drug-Like Properties.

J Med Chem · 2026 · PMC12910667 · PMID 41571452

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closest p

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boldest claim

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a clear trendno p-value reported

Overall, although there did not appear to be a clear trend with the introduction of the additional nitrogen or the position of the amide bond around the indole ring, the new analogs maintained binding affinity and selectivity at the MOR compared to NAN .

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