Although anti-BTLA agonist antibody treatment showed a tendency to reduce astrocyte activity (GFAP-positive cells, t = 1.681, P = 0.1236) and neurodegeneration (FJB-positive cells, t = 1.394, P = 0.1936) in the perihematomal regions on day 3 after ICH, these effects did not reach statistical significance (Fig. 4 A and C).
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BTLA-mediated regulation of neuroimmune responses enhances recovery after intracerebral hemorrhage.
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