Preventive effect of liraglutide on postoperative delirium in elderly patients undergoing cardiac surgery: protocol for a single-centre, randomised, double-blind, placebo-controlled trial.

23 24 In addition, a recent multicentre randomised controlled trial in cardiac surgery patients reported that perioperative liraglutide administration improved glycaemic control and showed a trend towards reduced POD incidence, although statistical significance was not achieved, possibly due to younger patient age, lower baseline surgical risk and a lower than expected delirium incidence in the control group. 25 Importantly, liraglutide was well tolerated, with no significant increase in gastrointestinal adverse events (AEs) compared with placebo.

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