Unveiling the shared etiology between gastrointestinal disorders and valvular heart diseases through a genome-wide pleiotropy study.

Although no locus showed Bonferroni-significant convergence between both VHD and gastrointestinal disorders, five genes ( CFDP1 , STAT3 , IMPDH2 , UBE2L3 , and STMN3 ) presenting Bonferroni-significant association with at least one of the gastrointestinal disorders tested (Supplementary Table 6A ) also had a nominally significant effect on VHD (SMR P < 0.05, HEIDI P > 0.05; Supplementary Table 6B ).

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