SK channel upregulation and sex-specific mechanisms drive spinal motoneuron reduced excitability with age.

For ascending FI gain, the overall correlation across all MNs was marginally significant ( p = 0.057, black trace in Figure 5A and Supplementary Table 2 ); however, a significant positive correlation was observed specifically in male MNs ( p = 0.049, blue trace in Figure 5A and Supplementary Table 2 ).

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Although slow MNs displayed similar directional trends, these effects did not reach statistical significance, likely due to limited sample sizes (light bars in Figures 6D – F and Supplementary Table 5 ).

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