Identification and validation of an 11-kinase signature that predicts chemo- and radiosensitivity in gastric cancer.

For ACRG subclusters, 67.2% (43/64) of MSI and 73.3% (33/45) of MSS/EMT tumours corresponded to the EMT subgroup, whereas 69.0% (49/71) of MSS/TP53+ tumours associated with metabolism subgroup, contributing to a highly significant statistical correlation between our kinase signature and ACRG subtyping (P < 0.0001; Chi-square test; Table S5 , Fig. 5 E), although no ACRG subgroup exactly matched one of our kinase-defined subgroups.

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Contrary to expectations, the subgroups predicted to be chemoresistant still demonstrated significant survival benefit post-chemotherapy, or a strong trend for this ( Figure S4E and F ).

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