Real-World Data on Barrigel and SpaceOAR Rectal Spacers in Prostate Cancer Radiation Therapy: A Comparative Analysis.

Adv Radiat Oncol · 2026 · PMC12915168 · PMID 41716956

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0800

boldest claim

The sentences

nearing significanceP = .06so close (0.05 < p ≤ 0.1)

When RSV was restricted to ranges of 6 to 13 cc, Barrigel achieved better median rectal doses for v57 and v54 ( P = .01 for both), and nearing significance for v47 ( P = .06, Fig. 4a ).

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approached significanceP = 0.08so close (0.05 < p ≤ 0.1)

However, for the 5-fraction regimen, fewer significant differences were observed, with v32, v30, and v20 showing significance ( P = .03, .01, .04, respectively), whereas v36 and v34, approached significance ( P = 0.08, P = .06).

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a numerical trendno p-value reported

The SpaceOAR RCT showed statistically significant improvements in bowel QOL up to 3 years, whereas the Barrigel RCT showed a numerical trend toward improved bowel QOL at 3 to 6 months, but this was not statistically significant.

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