Multi-omics profiling of acute <i>Pseudomonas aeruginosa</i> pneumonia unmasks conventional NK cell depletion and stage-specific therapeutic targets.

Figure 7(a) shows the overall immune infiltration score, with an overall trend of increasing immediately after infection and then decreasing, suggesting that large numbers of immune cells were recruited to the lung after infection, rapidly provoking an inflammatory response, with the most intense immune cell infiltration in the lung at 24 hpi, followed by the beginning of reduced inflammation.

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Our flow cytometry results showed a decreasing trend in AM numbers after infection, verifying the fact that PA infection leads to AM apoptosis.Recent findings indicate that PA infection triggers a swift activation of acid sphingomyelinase (Asm), resulting in the creation of ceramide-enriched biofilm platforms.

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The number of differentially expressed genes upregulated and downregulated at each time point showed a trend of increasing and then decreasing, suggesting a transitional process of inflammation generation and regression ( Figure 4(f) ).

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