Association of Alzheimer's disease progression with YKL40 levels in peripheral blood and cerebrospinal fluid: a systematic review and meta-analysis.

Front Neurol · 2026 · PMC12916370 · PMID 41725729

Europe PMC DOI

hedged sentences

0.1340

closest p · 2.7× alpha

0.5300

boldest claim

The sentences

failed to reach significancep = 0.134not close (p > 0.1)

Stratified analyses based on diagnostic criteria and female proportion revealed significantly elevated CSF YKL-40 levels in AD patients compared to those with MCI (all p < 0.05) ( Table 4 ), whereas the overall meta-analysis incorporating all studies failed to reach significance ( p = 0.134) ( Figure 5 ), suggesting that different diagnostic criteria and imbalanced gender distribution may serve as confounding factors contributing to the high heterogeneity observed in this study. 3.4.

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an increasing trendp = 0.53not close (p > 0.1)

did not reach statistical significancep = 0.53not close (p > 0.1)

Notably, while CSF YKL-40 levels in AD patients showed an increasing trend compared to MCI patients, this difference did not reach statistical significance ( p = 0.53).

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