1-Deoxynojirimycin with theaflavins ameliorates high-fat diet-induced insulin resistance in mice by modulating the gut microbiota.

Although the regulatory effects on Claudin-1 and Mucin 2 did not reach statistical significance in all analyses, the consistent restoration of their expression trends also provides potential benefits for improving comprehensive intestinal barrier function. 3.3 1-DNJ and TFs combination modulated gut microbiota in HFD-induced IR mice The bioinformatics analysis of 16S rRNA gene sequencing data revealed that high-quality sequences were clustered into 1,621 Amplicon Sequence Variants (ASVs) at a 97% similarity threshold following processing by clustering algorithms.

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However, no significant differences were observed among the 1-DNJ, TFs, and 1-DNJ + TFs groups relative to the Model group, although an increasing trend was noted.

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