Multi-epigenome-wide analyses and meta-analysis of child maltreatment in judicial autopsies and intervened children and adolescents.

Mol Psychiatry · 2026 · PMC12916479 · PMID 40957904

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

showed a trendP = 0.06so close (0.05 < p ≤ 0.1)

Indeed, methylation at this site correlated significantly with depressive symptoms (DSRS-C; r = 0.37, P = 4.1E–05) and showed a trend-level correlation with behavioral and social difficulties (SDQ; r = 0.17, P = 0.06).

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marginally significantno p-value reported

In the Adolescent cohort, cg05646433 ( CHST11 ) methylation positively correlated with both SDQ and DSRS-C scores, cg02564536 ( ATE1 ) negatively correlated with SDQ scores, and cg04794662 ( FOXP1 ) showed marginally significant positive correlations with both measures (Fig. 3F , Supplementary Table S11 ).

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