Lipoprotein(a) and plaque progression: insights from serial coronary computed tomography angiography and quantitative plaque assessment.

A sensitivity analysis using an Lp(a) cutoff of 50 mg/dL yielded consistent associations for baseline plaque burden, with similar trends for LAP progression that did not reach statistical significance ( Supplementary Table S1 ). 3.4.

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Moreover, our study observed that even in seemingly low-risk populations such as those aged <60 years and with normal lipid profiles show a notable trend toward greater progression in total plaque volume especially in non-calcified plaque volume.

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