Comprehensive analysis of complement activation in a hydroxyurea-treated patient cohort with sickle cell disease.

38 Factor B levels were decreased in patients during early crisis compared with late crisis (approaching significance, P = .0503), which may indicate increased AP activity in early crisis as Factor B is consumed, and is consistent with work by others. 39 Overall, these analyses could benefit from larger cohorts, which may yield more robust results.

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Additionally, complement deposition (C3b and C5b-9) had a nonsignificant trend for an inverse relationship with the number of days patients were hospitalized for crisis.

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