Comparative efficacy of digital health interventions for depression and anxiety symptoms in adolescents and young adults: a systematic review and bayesian network meta-analysis.

Child Adolesc Psychiatry Ment Health · 2026 · PMC12918560 · PMID 41691290

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a favorable trendno p-value reported

Other interventions, such as TEII (SMD = 0.48) and TWDT (SMD = 0.37), also showed trends of being showed a favorable trend to the control group, but with wider confidence intervals and greater uncertainty.

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did not reach statistical significanceno p-value reported

However, for depression, the improvement associated with CBT-DI did not reach statistical significance (SMD = 0.44, 95% CrI: -0.02 to 0.91), suggesting that the high ranking probability reflects a potential trend rather than confirmatory evidence of superiority.

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