Proinflammatory cytokines modify Ca<sup>2+</sup> signaling and induce an apoptotic lipidome in murine small intestinal organoids.

Analysis of the circularity with ImageJ (defined as (4π*area)/perimeter 2 ; 1 = perfect circle; 0 = elongated polygon) revealed a trend for a more roundedness after cytokine incubation (0.78 ± 0.03, n = 15 organoids) compared with untreated controls (0.66 ± 0.05, n = 14 organoids), albeit this did not reach statistical significance (p = 0.067).

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