Genetic association of miR-146a, miR-196a2, and miR-499 polymorphisms with hepatocellular carcinoma risk in an Eastern Chinese population.

Specifically, while the miR-499 rs3746444 recessive model showed a nominally significant association ( P = 0.048), this association was no longer significant after Bonferroni correction. 4 Discussion MicroRNAs (miRNAs) have emerged as pivotal regulators of gene expression and tumorigenesis, acting as either oncogenes or tumor suppressors depending on the cellular context ( 16 ).

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Fourth, the association observed for miR-499 rs3746444 demonstrated borderline significance, with the lower bound of the 95% confidence interval approaching 1.0.

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