A multimodal biological margin risk index predicts recurrence after neoadjuvant immunochemotherapy in head and neck squamous cell carcinoma.

Front Immunol · 2026 · PMC12920489 · PMID 41727460

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did not reach statistical significanceno p-value reported

Finally, the immune contexture domain received a slightly lower weight (20%), as its high-risk exhausted phenotype was a consistent significant predictor (HR = 3.80 for LRC; HR = 4.25 for DMFS), but its intermediate risk category did not reach statistical significance.

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highly significantno p-value reported

In stark contrast, integrating the MRIx into the clinical model resulted in a dramatic and highly significant enhancement for predicting both LRC and DMFS.

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