Effect of norepinephrine initiation timing on mortality in septic shock: a multicenter cohort study.

BMC Anesthesiol · 2026 · PMC12922425 · PMID 41549241

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an increasing trendno p-value reported

When analyzing the spline curves illustrating aOR for 28-day mortality according to NE initiation time, the Sepsis-3 shock group revealed an increasing trend in the aOR over the time to NE administration (Fig. 2 ).

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did not reach statistical significanceno p-value reported

When using either the 1–3 h interval (aOR 0.85, 95% CI: 0.69–1.03, P = 0.103) or the 3–6 h interval (aOR 0.78, 95% CI: 0.59–1.03, P = 0.07) as reference points in the Sepsis-3 shock group, the association between NE administration within 1 h and reduced mortality did not reach statistical significance.

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