Pneumococcal vaccine for prevention of acute otitis media in children: a meta-analysis.

By vaccine type: PCV7 (RR = 0.89, 95% CI: 0.74–1.06) and PCV10 (RR = 0.56, 95% CI: 0.08–3.95) showed a trend toward a lower incidence of AOM compared with controls, whereas PCV13 + PCV10 (RR = 3.00, 95% CI: 2.91–3.10, p < 0.001) and PCV13 (RR = 1.20, 95% CI: 1.05–1.37, p = 0.007) were associated with a significantly higher incidence of AOM (Figure S4 ).

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The results demonstrated a slight trend toward a higher incidence of acute mastoiditis in the vaccine group compared with the control group (RR = 1.70, 95% CI: 0.71–4.07) (Fig. 6 ).

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