Efficacy of various interventions for the management of white spot lesions associated with fixed orthodontic treatment: a systematic review and network meta-analysis of randomized controlled trials.

BMC Oral Health · 2026 · PMC12925361 · PMID 41723426

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did not reach statistical significanceno p-value reported

Other interventions, including ozone, laser, nano-agents, probiotics, and NovaMin, did not reach statistical significance (Fig. 3 & Table S3).

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