A genome-wide association study of buccal mucosa cancer in India and multi-ancestry meta-analysis discovers risk loci and gene-environment interactions.

EBioMedicine · 2025 · PMC12926300 · PMID 41318233

Europe PMC DOI

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closest p · 1.0× alpha

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boldest claim

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nominally significantP < 0.05actually significant

Indeed, we noted that several nicotinic receptor encoding genes ( CHRNA3/4/5/6 and CHRNB1/4 ) showed weak but nominally significant (P < 0.05) associations in the MAGMA analyses ( Supplementary Table S13 ).

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likely to be significantno p-value reported

Genetic correlation analysis of the Indian BMC GWAS and EA OC GWAS further indicated that while there is substantial overlap in the underlying genetic architecture, there is also likely to be significant heterogeneity due to differences in the site of cancer, underlying environmental exposures, and other population characteristics.

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