Barely Significant
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Early metoprolol use in ICU patients with congestive heart failure is associated with increased 30-day mortality: a causal machine learning study.

Front Pharmacol · 2026 · PMC12926445 · PMID 41737558

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Although the ATE of early metoprolol use on extended 48-h medication use and in-hospital mortality was consistent with the primary analysis, it did not reach statistical significance.

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