<i>In vitro</i>-<i>in vivo</i> discord: A preclinical study of AZD2716 and its racemate with comparison to varespladib for the development of snake venom sPLA2 inhibitors.

Using a linear model with species-clustered standard errors estimated a viperid-elapid difference of 0.473 log units for AZD2716 and 0.553 for racemate, though these values did not reach statistical significance after Holm adjustment (p = 0.13, p = 0.11 respectively). 3.2 In vivo mouse studies We tested the effects of AZD2716, its racemate, and varespladib treatment on acute venom-induced toxicity following experimental administration of venoms from the four different species of snake for which we could make direct comparisons between studies using the same venom and drug lots— M. fulvius (Eastern coral snake), O. scutellatus (Coastal Taipan), C. scutulatus (Mojave Rattlesnake), and D. russelii (Russell's viper).

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