Signal peptide peptidase- and SPP-like 3-dependent shedding of α1,6-fucosyltransferase differentially affects core fucosylation.

In addition, the secretion levels of Y24A, I25A, H28A, and L29A mutants showed an increasing trend, although the differences did not reach statistical significance ( Fig. 4 B ; Sup, lanes 3–4, 7–8 and 4C), suggesting that these residues play key roles in FUT8 cleavage.

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