Changes in waist circumference (WC) and triglycerides (TGs) did not reach statistical significance in the primary analysis (WC: SMD [95% CI] −0.1562 [‐0.3138; 0.0015], I 2 = 0.0%, p ‐value (heterogeneity) = 0.7572; TG: SMD [95% CI] −0.1668 [‐0.7979; 0.4642], I 2 = 97.7% p value (heterogeneity) < 0.0001); however, after publication‐bias adjustment using the trim‐and‐fill sensitivity analysis, meaningful reductions were discovered for WC (SMD (%95CI): −0.1712 [‐0.3248; −0.0176], I 2 = 0.0%, p value (heterogeneity) = 0.7696) and TG (SMD (%95CI): −0.8900 [‐1.6619; −0.1181], I 2 = 97.9%, p value (heterogeneity) < 0.0001).
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Long-Term Effects of Orlistat on Lipid Metabolism and Anthropometric Indices: A Meta-Analysis of Clinical Trials.
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