Barely Significant
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Long-term public antibiotic awareness campaign significantly reduced inappropriate antibiotic use in pediatric primary care settings.

Front Public Health · 2026 · PMC12928503 · PMID 41737609

3
hedged sentences
0.1500
closest p · 3.0× alpha
0.1500
boldest claim

The sentences

a negative trendp = 0.15not close (p > 0.1)
Across the entire timeframe, the compound annual growth rate (CAGR) was modestly positive (+0.69% per year), whereas the linear regression slope indicated a negative trend (−0.82 percentage points per year; β = −0.46, p = 0.15, R 2 = 0.22), confirming a non-linear pattern.

also in 1,766 other papers

an increasing trendno p-value reported
Cefixime, a notable third-generation cephalosporin, rose from 5% in 2016 to 14% in 2021, indicating an increasing trend in the utilization of more potent oral cephalosporins.

also in 29,988 other papers

marginally significantno p-value reported
Although marginally significant, the post-campaign trend indicates an intensified and progressive decline consistent with a cumulative educational effect. 3.5.3 Autocorrelation-adjusted regression (Prais–Winsten, AR (1)) After adjusting for serial correlation, the pre-2016 decline was reduced and rendered non-significant (−16.98 per 1,000 children per year; p = 0.638).

also in 8,164 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.