Disrupted Tryptophan Metabolism Mediates Manganese-Induced Neurogenesis and Neuroinflammatory Impairments: Rescue by Exogenous Melatonin.

At KEGG Level 1, metabolism-related pathways were significantly upregulated, while environmental information processing pathways were decreased in the Mn group ( Figure D). At KEGG Level 3, PCoA analysis again showed distinct clustering between groups ( Figure E), although ANOSIM analysis did not reach statistical significance ( p = 0.05).

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