IL-35 enhances IL-10⁺ breg-mediated immunoregulation and attenuates inflammation and fibrosis in systemic sclerosis.

Arthritis Res Ther · 2026 · PMC12930626 · PMID 41618457

Europe PMC DOI

hedged sentences

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closest p · 1.0× alpha

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boldest claim

The sentences

a decreasing trendP > 0.05actually significant

Although the Th1/Th2 ratio showed a decreasing trend, the difference was not statistically significant ( P > 0.05).

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did not reach statistical significanceP > 0.05actually significant

Following rhIL-35 intervention, numerical increases were observed in the proportions of IL-35+ Bregs and CD19+CD138+ cells, although these changes did not reach statistical significance ( P > 0.05).

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