Large-scale mapping of the MCH network in ALS mice reveals the vulnerability of dopaminergic and GABAergic neurons in zona incerta.

Acta Neuropathol Commun · 2026 · PMC12930930 · PMID 41652471

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closest p · 1.6× alpha

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a strong trendp = 0.08so close (0.05 < p ≤ 0.1)

While the inputs from other cortical subregions remain unchanged between genotypes a strong trend for the effect of mutant SOD1 was noticed by 2-way ANOVA in both rabies titer cohorts (LT: F1,120 = 3.07, p = 0.08; HT: F1,80 = 3.43, p = 0.07) (Fig. 4 A, D).

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