Association between the CYP24A1 rs2762939 polymorphism and vascular calcification in Indonesian patients with chronic kidney disease on hemodialysis.

A study tested the association of CYP24A1 polymorphism and coronary artery calcification CAC in three populations, the Amish Family Calcification Study (AFCS), the Genetic Epidemiology Network of Arteriopathy (GENOA), and the Penn Coronary Artery Calcification (PennCAC) cohorts found that rs2762939 C allele consistently showed association with reduced coronary artery calcification, with meta-analysis yielding a highly significant result ( p =2.9×10 − 6) [ 5 ].

also in 132,142 other papers

In line with these observations, our results suggested that carriers of the C allele might have a potential protective effect against vascular calcification; however, the association did not reach statistical significance (OR 0.77; 95%CI: 0.38–1.56; p =0.592).

also in 111,027 other papers