A proteomics approach to identify predictive blood biomarkers for pleural mesothelioma in prospective cohorts.

Clin Exp Med · 2026 · PMC12932387 · PMID 41714836

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borderline significantno p-value reported

ELISA confirmed a borderline significant rise in beta‐2‐microglobulin within two years of diagnosis in EPIC.

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borderline significanceno p-value reported

Subsequent ELISA validation in the discovery cohort confirmed reproducible trends for B2M, C4, TF, and DCD, although only B2M demonstrated a borderline significance and association in cases sampled within two years of diagnosis.

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did not reach statistical significanceno p-value reported

TF, C4, and DCD trended similarly to discovery data but did not reach statistical significance.

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