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CD4-Based Chimeric Antigen Receptor (CAR)-T Cells With Resistance to HIV-1 Infection and Enhanced Anti-HIV Efficacy: Covalent Interaction Between CD4-CAR and HIV-1 Envelope Glycoprotein.

J Med Virol · 2026 · PMC12933161 · PMID 41736532

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In addition, D1C‐BB CD8+ CAR‐T cells were significantly more abundant in the spleens of treated mice at day 18, whereas CD4+ CAR‐T cell levels did not reach statistical significance (Figure 4G ).

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