Miquelianin and spiraeoside from <i>Filipendula ulmaria</i> mitigate α-synuclein accumulation in <i>C.elegans</i> and reduce the expression of neuroinflammatory cytokines in human microglia.

vehicle control, respectively), although these did not reach statistical significance and lower concentrations did not influence the heat resistance of the nematodes. 3.8 Sp and Mq suppress pro-inflammatory gene expression in microglial-like cells To evaluate whether FE and its constituents also exert anti-inflammatory effects, we investigated their impact on pro-inflammatory cytokine expression in the human microglial clone 3 (HMC3) cell line stimulated by LPS.

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