Comprehensive analysis of the deleterious nonsynonymous, non-coding SNPs and cancer variants of human aldo-keto reductase type 1 (AKR1C1) protein and their probable association with disease risk and progression: a computational study.

First, the prioritization step was exploratory in nature, and near-significant signals were considered in conjunction with biological relevance.

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High consensus was observed across the dataset, as many variants including A41T, C206R, and G20E showed 100% agreement across 12 predictive calls, yielding highly significant FDR p-values of 0.0004587.

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